Tuesday, April 07, 2015

Garcinone E in mangosteen

Mangosteen contains more than forty biologically active, natural chemical compounds called xanthones. Garcinone E, a xanthone derivative, is useful in cases of cancers of the stomach, lungs, and liver.
Garcinone E

Garcinone E belongs to the class of organic compounds known as 8-prenylated xanthones. These compounds containing a C5-isoprenoid group linked to a xanthone moiety at the 8-position. Xanthone is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring that carries a ketone group.

Studies reported that garcinone E one of six xanthones from mangosteen pericarp had potent cytotoxic effect on all hepatocellular carcinomas cells lines as well as on the other gastric and lung cancer (Ho, C., Huan, Y., Chen, C. 2002 Planta Med. 68, pp 975-979)

The researchers suggest that garcinone E may be potentially useful for the treatment of certain types of cancer.
Garcinone E in mangosteen 

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